Trapping Moving Targets with Small Molecules

Trapping moving targets with small molecules.

Structure-based drug design traditionally uses static protein models as inspirations for focusing on "active" site targets. Allosteric regulation of biological macromolecules, however, is affected by both conformational and dynamic properties of the protein or protein complex and can potentially lead to more avenues for therapeutic development. We discuss the advantages of searching for molecul...

INTERACTION OF PROTEINS WITH SMALL MOLECULES

Small Arms Survey 2012 : Moving Targets

The methods for estimating the annual global value of imports of parts and accessories are presented in Chapter 8 of the Small Arms Survey 2012, ‘Piece by Piece: Authorized Transfers of Parts and Accessories’ (Grzybowski, Marsh, and Schroeder, 2012, pp. 247–50). This annexe contains additional details on some of the data and estimation techniques used in the chapter, including for the estimate ...

Trapping molecules on chips

Correspondence: [email protected] 1Fritz-Haber-Institut der MaxPlanck-Gesellschaft, Faradayweg 4-6, 14195 Berlin, Germany 2Istituto Nazionale di Ottica-CNR & European Laboratory for Non-Linear Spectroscopy LENS, Via Nello Carrara 1, 50019 Sesto Fiorentino, Italy Abstract In the last years, it was demonstrated that neutral molecules can be loaded on a microchip directly from a supersoni...

Moving Targets

In addition to its well-known role in regulating blood pressure and fluid balance, the renin-angiotensin-aldosterone system (RAAS) has continued to fascinate both researchers and clinicians because of the several additional functions that it has been proposed to carry out. Disruption of the production or action of angiotensin II (Ang II) during development, either by gene mutation or by pharmac...